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Some of the most commonly reported benefits of psilocybin are: 

- the softening or dissolution of the “ego” (the part most responsible for negative beliefs and critical self-talk), 

- a mystical experience of connection to something more significant, 

- a greater sense of trust in self and the flow of life, 

- reworking of old memories or traumas, 

- expansive state of wonder or awe, 

- loving and open-hearted feelings, 

- more positive mood and ease when dealing with daily life stressors, 

- support with grief, 

- greater ability to break habits and compulsions or addictions, 

- insights into ourselves and others, 

- more creative outlook or access to inspiration, 

- and increased self-expression. 

The variety of psychedelic experiences is as varied as the humans doing them and the dosing options out there–so stay open-minded to what you might feel or find. Even someone doing the exact dosage for the fifth time can have a completely different experience than any of the times before. 

On the whole, some common themes when taking psilocybin are: 

- shifts in your brain’s default ways of functioning that lead to a decrease in negative or fear-based thinking,

- new perspectives on self and past events or traumas,

- increased creativity and sense of connectivity,

- and mystical experiences and feelings of unity or one-ness with something larger than the self, 

- and more empathy for self and others. 

When it comes to physical experiences, people often report the following: 

- Sensory sensitivity–heightened awareness of sights, sounds, smells and touch

- Changes in vision or perception – including distortions or hallucinations

- synesthesia (experiencing one sense through another–like sound as tastes or feelings as colors)

- Dizziness, light-headedness, or a loss of balance means that it may be easier to have the experience lying down than doing anything else

- Nausea or gastrointestinal symptoms

- Short-term disruption or delay of deep sleep

- Short-term increase in blood pressure, heart rate 

- Changes in body temperature

Contributing factors to these fluctuations include hormones (for women primarily), hydration, and headspace. 

Studies show that one’s mindset can change when one's setting changes. Unexpected interactions with medical staff or law enforcement may increase the risk of anxiety.

Research shows a correlation between bad trips as they relate to “health problems” when psilocybin is used with other substances, specifically alcohol.

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In general, ketamine is known to induce an expanded state of consciousness that can provide a deep and transformative experience of self and the broader world. 

On the whole, some common themes when taking Ketamine are : 

- shifts in your brain’s default ways of functioning that lead to a decrease in negative or fear-based thinking

- new perspectives on self and past events or traumas

- increased creativity and sense of connectivity

- mystical experiences and feelings of unity or one-ness with something larger than the self

- more empathy for self and others. 

When it comes to physical experiences people often report : 

- A deep sense of relaxation

- Decrease in physical pain 

- Sensitivity to light and sound 

- Visuals and imagery with eyes closed

- Dizziness and loss of balance or motor skills 

- Sense of an out-of-body experience

Contributing factors to these fluctuations include hormones (for women primarily), hydration, and headspace. 

Several factors can contribute to a difficult ketamine session, including:

- Ingesting alcohol within 24-48 hours prior to taking ketamine 

- Getting sick or disoriented 

- Being uncomfortable or unfamiliar with a loss of control 

- Feeling overwhelmed by emotion or by the experience

- Underlying or undiagnosed mental health conditions 

- Too high of a dose

- Personal history of mental health issues or trauma 

Ketamine does not interact well with alcohol, and there can be significant negative side effects ranging from loss of consciousness to nausea and emotional distress when they are mixed. Physicians suggest abstaining from alcohol for 48 hours before and after using ketamine.