SetSet created this Guide to Psilocybin to help safely explore microdosing psilocybin mushrooms.
What is Microdosing?
Microdosing is taking a sub-perceptual dose of a psychedelic substance, such as psilocybin mushrooms, to enhance creativity, focus, and mood.
Am I a Good Candidate for Microdosing?
Before embarking on a microdosing protocol, it's essential to consider whether you are a good candidate for this type of treatment. Several factors are to be considered, including pre-existing health conditions and current medications.
- Pre-existing conditions, including bipolar, schizophrenia, psychosis
- What about my prescription meds? Is it safe to taper?
- Contraindications with SSRIs, SNRIs, anti-psychotics, MAO inhibitors
If you have a personal or family history of bipolar, schizophrenia, psychosis, or other mood disorders, you must talk to your healthcare provider before starting a microdosing protocol. Psilocybin has been shown to have positive and negative effects on mood, so it's critical to understand the potential risks and benefits before beginning treatment.
If you are taking prescription medications, talking to your healthcare provider before starting a microdosing protocol is essential. Some medicines, such as SSRIs, SNRIs, anti-psychotics, and MAO inhibitors, can interact with psilocybin and may cause unwanted side effects.
Overall, it's vital to approach microdosing cautiously and talk to your healthcare provider before beginning treatment. They can help you determine whether this type of treatment is right for you and guide you on safely incorporating it into your healthcare regimen.
Dosage is perhaps one of the trickiest aspects of the magic mushroom experience, so asking how much to take is an important and responsible part of the process. No two trips, even the same dosages to the same person, will result in identical trips. Daily differences in naturally occurring body chemicals and in the foods we ingest will impact the effects of a psychedelic chemical.
This potency chart is a good guide to potency and experience. Remember that these are general effects and more potent strains like Penis Envy will present these qualities more intensely.
The recommended dose for beginners and those looking for a mild “trip”
MICRODOSE: 0.08 - 0.3 grams
10-20% of a standard dose, microdosing is reported to enhance creativity, focus, and mood without experiencing any notable side effects such as hallucinations or other significant changes in perception.
MUSEUM DOSE: 0.4 - 0.75 grams
A museum dose is noticeably felt on the physical and cerebral planes. One may experience increased euphoria, weightlessness, and awe but not so intoxicated as to be inhibited from general motor skills such as walking or speaking.
The recommended dose for beginners and those looking for a moderate to moderately intense “trip”
LOW DOSE: 0.5 - 1.5 grams
You won’t completely dissociate at this dosage level and should be able to interact with your environment and other people relatively normally. These interactions may be more significant to you or seem very amusing. Any hallucinations will be subtle with eyes open, though perhaps more pronounced with eyes closed.
MEDIUM DOSE: 1.5 - 3.0 grams
At this dosage, you will experience a “proper” psychedelic trip. With eyes both open and closed, you may experience visual changes, enhanced colors, unexpected sounds, and possibly slight hallucinations plus signs of introspective awakenings.
The recommended dose for experienced psychonauts and those looking to “trip hard”
HIGH DOSE: 3.0 - 5.0 grams
Expect intense changes in visuals, thought patterns, and feelings. We advise to only ease into this dosage if a lesser dosage is not reacting in your body after an hour. It is likely you will hallucinate extreme perceptual distortions, and go on a wild mental journey with possible ego dissolution.
HERO DOSE: 5+ GRAMS
Expect disconnection from consensus reality. A heroic dose, in its early stages, presents all of the effects of lower doses but rapidly progresses to a unique and mind-blowing experience. Trippers can completely lose their sense of place and time so high potency is often best accompanied by a sitter. After a trip of this magnitude, take the time to process everything that happened to you.
Microdosing FAQ
Psilocybin remains a Schedule I substance under federal law. This workshop offers education and harm-reduction guidance. Attendees are responsible for complying with all local, state, and federal laws.
The effects of microdosing psychedelics are usually subtle and may last for several hours, depending on the substance and dose. Patients may notice mild improvements in mood, focus, and creativity without experiencing the intense hallucinations associated with higher doses.
You should never combine psilocybin with SSRIs or MAOIs without professional guidance. Always consult your prescriber.
Given psilocybin's legal status, obtaining it safely is challenging. Providers should advise patients to seek information from reputable sources and caution them against purchasing products from unverified or illegal markets. Emphasizing harm reduction practices and legal considerations is crucial.
Effective dosages for microdosing vary by substance but generally fall between 1/10th and 1/20th of a typical recreational dose. For example, an effective microdose of psilocybin might be around 0.1 to 0.3 grams of dried mushrooms.
If you experience visuals, nausea, or anxiety, it’s likely too much. Reduce your dose and track your experience.
Goals are future-oriented tasks. Intentions are present-moment energies guiding how you show up daily.
Some feel subtle shifts within a day or two. For others, it builds over weeks. Integration days - or days off from dosing - are often where emotional clarity arises.
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